Endoscopic ultrasound (EUS) is the most sensitive modality in detecting solid lesions of pancreas and is commonly performed for staging, and tissue acquisition. Correct pathologic diagnosis is crucial for timely diagnosis and initiation of therapy in cases of pancreatic adenocarcinoma and could preclude surgery for conditions (i.e. autoimmune pancreatitis) that mimic pancreatic cancer. Aim of our study was to evaluate overall impact of dedicated cytopathologists (DC) versus community pathologists (CP) on overall diagnostic accuracy of EUS guided tissue sampling.