The largest cause of mortality in patients with inflammatory bowel disease (IBD) remains thrombo-embolic disease (TED). Recent reports have demonstrated that both monogenic and polygenic factors contribute to TED and 10% of ‘healthy’ subjects are genetically at high risk for TED. Our aim was to utilize whole exome sequencing (WES) and genome-wide genotyping to determine the proportion of IBD patients genetically at risk for TED and investigate the effect of genetic risk of TED in IBD.