Zinc Dependent Regulation of ZEB1 and YAP1 Co-activation Promotes EMT Plasticity and Metastasis in Pancreatic Cancer

Posted on January 5, 2021 by Gastroenterology Journal

This study defines a novel ZIP4-miR-373-LATS2-ZEB1/YAP1-ITGA3 signaling pathway that meditates pancreatic cancer metastasis and EMT plasticity. The findings are highly translational to develop new personalized therapy for pancreatic cancer.

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