713b A Multi-Systems Approach with Big Data from Adverse Event Reporting and Health Records, Clinical Biospecimens, and Experimental Animal Data Reveal That Retinoids Impact Asparaginase-Associated Pancreatitis Outcomes in Leukemic Patients

Asparaginase is a crucial cornerstone chemotherapy for the most common cancer in children, acute lymphoblastic leukemia (ALL). However, a major concern is that 5-10% of all asparaginase users develop the painful, life-threatening complication of pancreatitis. Asparaginase-associated pancreatitis (AAP) is a more severe form of pancreatitis, and discontinuation of asparaginase is associated with inferior disease-free survival in high-risk cancer patients. Thus, there is a major unmet need to mitigate AAP.