Enterotoxigenic Bacteroides fragilis (ETBF) is strongly associated with the occurrence of inflammatory bowel disease(IBD), colitis-associated colorectal cancer (CAC) and colorectal cancer (CRC). However, the mechanism of ETBF-induced intestinal inflammation and tumorigenesis remains unclear.METHODS microRNA sequencing was utilized to detect the differentially expressed miRNAs both in ETBF-treated cells and exosomes derived from ETBF-inoculated cells. Cell Counting Kit-8 assays were used to evaluate the effect of ETBF and exosomes on CRC cell proliferation.