Approximately 4-23% of patients with IBD develop renal complications such as nephrolithiasis, glomerulonephritis, and tubulointerstitial nephritis, which may lead to chronic kidney disease (CKD). Furthermore, it has been shown that younger age of IBD diagnosis increases risk for CKD development and this association is not linked to use of common therapeutic agents for the treatment of IBD, suggesting a disease mediated association of IBD to CKD. IBD is characterized by increased intestinal epithelial permeability.