Diabetes mellitus (DM) is known to be associated with Pancreatic ductal adenocarcinoma (PDAC), particularly, new-onset DM (NODM). Others have developed polygenic risk scores (PRS) associated with PDAC risk. We aimed to compare the performance of these PRS in an independent cohort to determine if they can discriminate between NODM and long standing DM (LSDM) patients with PDAC.