Inflammatory diseases are often accompanied by behavioral changes or “sickness behaviors” that include apathy, social withdrawal, fatigue, and loss of appetite. These behaviors have likely evolved as protective adaptations to help deal with the acute phase of illness, but if an illness persists, they can become dominant symptoms exerting major adverse impact on quality of life.1,2 It has been proposed that the release of proinflammatory cytokines activates brain communication pathways that ultimately drive sickness behaviors, although the precise mechanisms remain poorly understood.