There has been significant progress in the study of extracellular vesicles (EVs) since the 2017 American Gastroenterological Association-sponsored Freston conference Extracellular Vesicles: Biology, Translation and Clinical Application in GI Disorders. The burgeoning interest in this field stems from the increasing recognition that EVs represent an understudied form of cell-to-cell communication and contain cargo replete with biomarkers and therapeutic targets. This short review will highlight recent advances in the field with an emphasis on colorectal cancer (CRC).