Aldehyde “Adduction” Explains Synergy of Smoking and Alcohol in Promoting Pancreatitis

Pancreatitis is the inflammatory disorder of the pancreas, which often forms a disease continuum starting with a so-called sentinel attack of acute pancreatitis (AP), followed by recurrent AP (RAP) episodes, and eventual progression to chronic pancreatitis (CP).1 The risk of recurrence after the first AP attack is ∼10% to 30%, and the risk of progression from RAP to CP is ∼25% to 35%.2–4 Progression after the sentinel episode of AP to RAP and ultimately to CP is often associated with environmental or genetic risk factors, or both.

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