Question: A 29-year-old man with severe colonic Crohn’s disease (CD) with perianal involvement was admitted with a 1-week history of painful, nonpruritic, erythematous skin rash associated with fever, chills, myalgias, and arthralgias. The lesions started as red, violaceous papules and progressed to painful plaques and nodules with some of them ulcerating into larger lesions. Patient also reported 6 to 7 episodes per day of large-volume, watery, nonbloody diarrhea and lower abdominal cramps. He had been experiencing frequent flares of his CD over the past year complicated by rectal abscess and anal fistula requiring surgical drainage and fistulotomy.