As the prologue to the first edition of Sternberg’s Surgical Pathology states, the surgical pathologist’s career can be very lonely. Our working environment is characterized by our relationship with our microscopes, our books becoming companions in distress. Nowadays, the Internet and Google’s engines have entered the panorama, assisting in keeping abreast of the latest news in this era of knowledge explosion. Although Google can be helpful in finding new and old entities as well as pictures and references, the added value of this textbook relies on the reasoning process when approaching a differential diagnosis, as well as in the comprehensive summary of the immunohistochemistry (IHC) and molecular findings to be considered in the differential diagnosis.