Apoptotic bodies can be found to be marginally increased in untreated IBD. However, the presence of more than 6 apoptotic bodies per 10 contiguous crypts warrants further investigation. Apoptotic enteropathy (AE) has been described in different conditions including Graft–versus–Host disease (GVHD), idiopathic AIDS enteropathy, chronic variable immunodeficiency, autoimmune enterocolitis, and viral infections. AE has also been reported as a side effect of various medications including: NSAIDS, Mycophenolic acid, 5–Fluorouracil, Ipilimumab, Capecitabine, Etanercept as well as inflammatory bowel disease (IBD) drugs-Methotrexate (MTX), Infliximab, and Adalimumab (ADA).