A20 (TNFAIP3) suppresses inflammation by interrupting the NF-kB pathway via its ubiquitin-editing activities. Several single-nucleotide polymorphisms (SNPs) have been shown to be associated with various autoimmune and inflammatory diseases, including IBD. Two such SNPs are rs146534657 (A305G) and rs2230926 (T380G) have minor allele frequencies of 0.1-1.3% and 6.1-17.9%, respectively. We investigate the frequencies of these SNPs in our majority (>60%) Hispanic population and explore their clinical impacts on IBD.