P074 MICROBIAL COMPOSITION IS EFFECTIVELY IMPROVED BY COMBINATION THERAPY WITH FECAL MICROBIAL TRANSPLANTATION AND MULTIPLE ANTIBIOTICS FOR ULCERATIVE COLITIS

Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection. To provide effective FMT protocol for ulcerative colitis (UC) has been desired. We previously reported that the combination therapy with multiple antibiotic therapy (AFM: amoxicillin, fosfomycin and metronidazole) and FMT (Antibiotic FMT: A-FMT) synergistically contributes to the recovery of the phylum Bacteroidetes composition, which is associated with high clinical response for UC. Here, we constructed further additional microbial analyses at the species level to confirm whether Bacteroidetes species from donors actually colonized and contribute to its effective transplantation.

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