P062 INTEGRIN ß7 DEFICIENCY RESULTS IN PAUCITY OF TERTIARY LYMPHOID TISSUES AND DECREASED LAMINA PROPRIA IGA+ B CELLS LEADING TO MICROBIOME DYSBIOSIS AND WORSE INFLAMMATION IN A MODEL OF CROHN’S-LIKE ILEITIS

Integrin α4β7 expression on lymphocytes promotes their localization to the gut. A monoclonal antibody against these integrins (i.e. vedolizumab) is safe and effective treatment for inflammatory bowel disease (IBD). Given the importance of integrins on IBD pathogenesis, we evaluated the role of integrin β7 (Itgb7) in a model of Crohn’s-like ileitis, the TNFΔARE mouse.