Tofacitinib is an oral, small molecule Janus kinase (JAK) inhibitor that is being investigated for IBD. In a recent trial of Crohn’s disease (CD) patients (pts), small treatment effects for tofacitinib vs placebo (PBO) were noted using CD Activity Index (CDAI)-based enrollment criteria without endoscopic scoring (1). We report post-hoc analyses of efficacy endpoints (CDAI-based and composite outcomes) in subgroups based on objective baseline (BL) criteria of disease activity.