PNPLA3, TM6SF2 and MBOAT7 Genotypes and Coronary Artery Disease

Nonalcoholic fatty liver disease (NAFLD) is projected to be the most common cause of end-stage liver disease requiring transplantation by 2025.1 The principal cause of death, however, is cardiovascular disease. In a recent meta-analysis, NAFLD—as diagnosed by either imaging or histology—was associated with an increased risk to develop cardiovascular disease, independent of all classical cardiovascular risk factors (odds ratio odds ratio, 1.69; 95% CI, 1.11-2.58).2

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