I read with great interest for the article by Satishchandran et al.1 The authors have shown that the beneficial role of hepatic miR-122 in patients and mice with alcoholic liver disease (ALD) was modulated by grainyhead-like transcription factor 2 (GRHL2) to regulate hypoxia-inducible factor 1 alpha (HIF1α). However, the multiple effects of miR-122 on ALD remain worthwhile to investigate.