We would like to thank Liu and colleagues for their letter with regards to our study entitled, “Variation in Interleukin 6 Receptor Gene Associates with Risk of Crohn’s Disease and Ulcerative Colitis.”1 In summary, the additional analysis carried out by the authors of the letter using summary statistics from the more recent (but smaller) de Lange2 meta-analysis supported the association of genetically increased s-IL-6R and IL-6 levels (as a proxy for interleukin 6 receptor blockade) with Crohn’s disease (CD), but not ulcerative colitis (UC).