Author Archives: Christina Dargel, Michal Bassani-Sternberg, Julia Hasreiter, Fabio Zani, Jan-Hendrik Bockmann, Frank Thiele, Felix Bohne, Karin Wisskirchen, Susanne Wilde, Martin F. Sprinzl, Dolores J. Schendel, Angela M. Krackhardt, Wolfgang Uckert, Dirk Wohlleber,

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

Posted on June 4, 2015 by Christina Dargel, Michal Bassani-Sternberg, Julia Hasreiter, Fabio Zani, Jan-Hendrik Bockmann, Frank Thiele, Felix Bohne, Karin Wisskirchen, Susanne Wilde, Martin F. Sprinzl, Dolores J. Schendel, Angela M. Krackhardt, Wolfgang Uckert, Dirk Wohlleber,

Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of all hepatocellular carcinomas (HCC), but not in healthy liver tissue or other organs. We aimed to generate T ce… Continue reading →

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