Author Archives: Gastroenterology Journal
Off-the-shelf PSCA-directed chimeric antigen receptor natural killer cell therapy to treat pancreatic cancer
Pancreatic cancer (PC) is the third leading cause of cancer-related death with a 5-year survival rate of approximately 10%. It typically presents as a late-stage incurable cancer and chemotherapy provides modest benefit. Here, we demonstrate the feasib… Continue reading
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Early life: an important window of susceptibility for colorectal cancer
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Design of clinical trials for mild-to-moderate ulcerative colitis
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“Broadening our understanding of the immune landscape in Lynch syndrome”
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Colorectal cancer screening in IBD – can characterization of GI microbiome signatures enhance neoplasia detection?
Current non-invasive CRC screening methods are not optimized for persons with IBD, requiring patients to undergo frequent interval screening via colonoscopy. Although colonoscopy-based screening reduces CRC incidence in IBD patients, rates of interval … Continue reading
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The insightful clarification of miR-144 mediated metabolic dysfunction
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Prevalence and Predictors of Young-Onset Colorectal Neoplasia: Insights from a Nationally Representative Colonoscopy Registry
A disturbing increase in early-onset colorectal cancer (EOCRC) has prompted recent guidelines to recommend lowering the CRC screening starting age from 50 to 45 years old for average risk individuals. Little is known about the prevalence of colorectal … Continue reading
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Liver Mass: Thinking out-of-the box
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Time to revisit disease classification in IBD: is the current classification of IBD good enough for optimal clinical management?
Inflammatory bowel disease (IBD), historically subdivided into Crohn’s disease and ulcerative colitis, is a very heterogeneous condition. While the tendency in medicine is to try and reduce complexity, IBD is a disease that cannot justify a one-size-fi… Continue reading
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Evolving short- and long-term goals of management of IBD: getting it right, making it last
Short- and long-term treatment targets in inflammatory bowel diseases (IBD) evolved during the last decade, shifting from symptom control to endoscopic healing and patient-centered parameters. STRIDE-II consensus placed these targets on a timeline from… Continue reading
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