Author Archives: Gastroenterology Journal
A young woman with recurrent rectal bleeding
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Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure
Sulfoconjugation of small molecules or protein peptides is a key mechanism to ensure biochemical and functional homeostasis in mammals. The PAPS synthase 2 (PAPSS2) is the primary enzyme to synthesize the universal sulfonate donor 3′-phosphoadenosine 5… Continue reading
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The maze of systemic therapy for hepatocellular carcinoma: did we find the compass?
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Surveillance imaging in individuals at high-risk for pancreatic cancer: Not a ceiling, but rather a floor upon which to build
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Gut microbiome metabolism drives the resolution of patients with COVID-19
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Adding Fuel to The Fire? A Role of Intraepithelial Lymphocytes in Enteric Immune Responses to SARS-CoV-2 Infection
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In Memoriam: Dawn Tranchino Provenzale, MD, MS (August 18, 1955 – April 22, 2021)
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MNX1-HNF1B axis is indispensable for intraductal papillary mucinous neoplasm lineages
Chromatin architecture governs cell lineages by regulating the specific gene expression; however, its role in the diversity of cancer development remains unknown. Among pancreatic cancers, pancreatic ductal adenocarcinoma (PDAC) and intraductal papilla… Continue reading
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Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development
There is a major unmet need to assess the prognostic impact of anti-fibrotics in clinical trials due to the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression. Continue reading
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Inadequate Rectal Pressure and Insufficient Relaxation and Abdominopelvic Coordination in Defecatory Disorders
Diagnostic tests for defecatory disorders (DDs) asynchronously measure anorectal pressures and evacuation and show limited agreement; thus, abdominopelvic-rectoanal coordination in normal defecation and DDs is poorly characterized. We aimed to investig… Continue reading
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