Author Archives: Gastroenterology Journal
Stem Cells, Helicobacter pylori and Mutational Landscape – Utility of Pre-Clinical Models to Understand Carcinogenesis and to direct Management of Gastric Cancer
Several genetic and environmental factors increase gastric cancer (GC) risk, with Helicobacter pylori being the main environmental agent. GC is thought to emerge through a sequence of morphological changes that have been elucidated on the molecular lev… Continue reading
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Patients with Adenocarcinoma of the Esophagus or Esophagogastric Junction Frequently Have Potential Screening Opportunities
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Racism is a Modifiable Risk Factor: Relationships Between Race, Ethnicity, and Colorectal Cancer Outcomes
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Advancing health equity for Medicaid beneficiaries by adding colorectal cancer screening to the CMS Adult Core Set
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BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation
Pancreatic ductal adenocarcinoma (PDAC) is characterized by severe metabolic stress due to fibrosis and poor vascularization. BZW1 is an eIF5-mimic protein involved in tumorigenesis and progression. The aim of this study was to investigate the role of … Continue reading
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Racial Disparity Between Whites and African Americans in Incidence and Outcome of Pancreatic Cancer: Have We Made a Difference?
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Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Acinar to Ductal Metaplasia (ADM) is the prerequisite for the initiation of Kras-driven pancreatic adenocarcinoma (PDAC) and candidate genes regulating this process are emerging from GWAS studies. The adaptor protein p130Cas emerged as a potential PDAC… Continue reading
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Trends and Projections in National U.S. Healthcare Spending for Gastrointestinal Malignancies (1996-2030)
The management of gastrointestinal (GI) cancers is associated with high healthcare spending. We estimated trends in US healthcare spending for patients with GI cancers between 1996 and 2016, and developed projections to 2030. Continue reading
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Bile Acid Diarrhea Is Associated with Increased Intestinal Permeability Compared to Irritable Bowel Syndrome-Diarrhea
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Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts
The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, an inability to breakdown and absorb sucrose and isomaltose. Children with this condition experienc… Continue reading
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