Author Archives: Gastroenterology Journal

An antigenically diverse, representative panel of envelope glycoproteins for HCV vaccine development

Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the genetic and antigeni… Continue reading

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Changes in metabolic syndrome status are associated with altered risk of pancreatic cancer: A nationwide cohort study

Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. Continue reading

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The Stanford Colonoscopy Quality Assurance Program: Lessons from the intersection of quality improvement and clinical research

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A microsatellite in the coding sequence of HLA-A/B is a mutation hotspot in colon cancer with microsatellite instability.

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Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Non-Recyclable Waste

Climate change has been described as the biggest global health threat of the 21st century1 and has significant implications for gastrointestinal (GI) health and disease,2 which is the focus of this consensus commentary provided by the World Gastroenter… Continue reading

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Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK blockade and CD40 Agonism

Pancreatic ductal adenocarcinoma (PDA) patients have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly immunosuppressive tumor microenvironment (TME). MEK inhibition combined with autophagy inhibition lead… Continue reading

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Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation

Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. Herein, we aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE). Continue reading

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Incidence and mortality in upper gastrointestinal cancer after negative endoscopy for gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with a decre… Continue reading

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COVID-19 mRNA Vaccine Short-Term Safety in Patients with Inflammatory Bowel Disease

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“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development

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