Author Archives: Gastroenterology Journal
713d Downregulation of Apolipoprotein H Induce Hepatocyte Steatosis to Promote Gut Microbiota Dysbiosis in Chronic Hepatitis B Infection
Apolipoprotein H (apoH) is produced by hepatocytes and also an acute phase protein in hepatitis B virus (HBV) infection. We found HBV and the large surface antigen upregulate apoH expression, which inhibits HBsAg secretion and then induces ER stress. A… Continue reading
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Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 2: Inactivated Vaccines
The effectiveness and safety of vaccinations can be altered by immunosuppressive therapies, and perhaps by inflammatory bowel disease (IBD) itself. These recommendations developed by the Canadian Association of Gastroenterology and endorsed by the Amer… Continue reading
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713e Longitudinal Analysis in A HNF4AΔIEC Mouse Colitis Model Reveals that Preclinical Flaring is Associated with Increased Akkermansia muciniphila Levels in the Gut Microbiome
As inflammatory bowel diseases (IBD) develop, the host’s homeostatic relationship with their microbiota changes. Early “preclinical” stages of colitis are relatively understudied, especially with respect to host-microbiota interactions. Intestinal epit… Continue reading
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713f Histologic Activity in Ulcerative Colitis Patients Achieving Endoscopic Healing is Associated with Higher Rate of Relapse and a Distinct Mucosal Microbial and Transcriptional Profile
Histologic remission (HR) in ulcerative colitis (UC) has been associated with better clinical outcomes. However, this therapeutic target is hard to achieve with the available medications. We aim to assess the relapse-free survival (RFS) of patients wit… Continue reading
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713a Mining the Gut Microbiota for Novel Procarcinogenic Microbes Reveals Clostridioides difficile as a Driver of Colonic Tumorigenesis
Microbial studies in colorectal cancer (CRC) have largely focused on three species: colibactin-producing E. coli, enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum. However, not all CRC patients harbor these organisms, suggesting that e… Continue reading
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AGA Clinical Practice Update on Strategies to Improve Quality of Screening and Surveillance Colonoscopy: Expert Review
The purpose of this American Gastroenterological Association Institute Clinical Practice Update was to review the available evidence and provide best practice advice regarding strategies to improve the quality of screening and surveillance colonoscopy…. Continue reading
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775c A Phase 2 Randomized Controlled Trial Demonstrating the Efficacy and Safety of Shr0302, A Selective JAK1 Inhibitor for the Treatment of Moderate to Severe Ulcerative Colitis Patients.
SHR0302 is a selective JAK1 inhibitor. A global, randomized, placebo-controlled phase 2 study (AMBER2; NCT03675477) consisting of an 8-week induction + 8-week extension period, was conducted to evaluate the efficacy and safety of SHR0302 in moderate to… Continue reading
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775f The Introduction of Faecal Immunochemical Testing as a Triaging Tool for Colorectal Cancer Investigation During the COVID-19 Pandemic. A Service Evaluation and Report.
The covid-19 pandemic has caused unprecedented difficulties within GI endoscopy. In the UK, this has included a five-week suspension of all non-emergency endoscopy from March 2020, followed by a prolonged recovery period. Endoscopy activity remains at … Continue reading
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775e Active Herpes Simplex Virus Type 1 Infection of the Gastric Mucosa is Associated with Functional Gastrointestinal Disorders: A Pilot Case-Control Study
Neurotropic herpes viruses establish lifelong latent infections in ganglionic neurons, including intrinsic enteric neurons and extrinsic neurons that project to the GI tract. Upon reactivation, virus replication within innervated tissues can result in … Continue reading
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PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis
Oral therapies targeting the integrin α4β7 may offer unique advantages for treatment of inflammatory bowel disease. We characterized the oral α4β7 antagonist peptide PTG-100 in preclinical models, and established safety, pharmacokinetic/pharmacodynamic… Continue reading
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