Author Archives: Gastroenterology Journal
Impact of Epic Smartlist and Lumens Software in Improving Op-29 Compliance at a Tertiary Health Care Network
OP-29 is a Centers for Medicaid and Medicare Services (CMS) measure to ensure that endoscopists recommend appropriate follow-up intervals after normal colonoscopy in average risk patients. Failure to report OP-29 compliance can adversely affect hospita… Continue reading
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Improving Physician Documentation of Anticoagulant and Antiplatelet Recommendations After Endoscopy: A Multifaceted, Longitudinal Quality Improvement Success Story at the Durham Veterans Affairs Medical Center
Careful post-procedural anticoagulation/antiplatelet (AC/AP) management is required to mitigate the risk of bleeding and/or thrombotic complications. Clearly documented recommendations for when to restart AC/AP medications after endoscopy are an essent… Continue reading
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A Quality Improvement Project on the Development of an Evidence-Based Management Algorithm for Iatrogenic Endoscopic Perforations and the Long Term Impact on Physician Knowledge
Acute iatrogenic endoscopic perforations (AIEP) can lead to serious complications and death. If identified immediately, perforations can be closed endoscopically with a 90% success rate. Knowledge of AIEP may decrease the associated morbidity and morta… Continue reading
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Assessment of Provider and Patient Knowledge of Pneumococcal Vaccination and Barriers to Vaccination in Inflammatory Bowel Disease
Prior studies have shown low pneumococcal vaccination rates among inflammatory bowel disease (IBD) patients, yet few have assessed barriers to vaccination. In addition, minimal data exist regarding gastroenterologist (GI) and primary care provider (PCP… Continue reading
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The Timing of Inpatient Diagnostic Paracentesis: An Opportunity to Improve
Prompt diagnostic paracentesis upon hospital admission to evaluate for spontaneous bacterial peritonitis (SBP) has been shown to decrease mortality and length of hospitalization. Time constraints of admitting physicians and lack of training in paracent… Continue reading
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Reduction of Chronic Steroid Use in Patients Discharged for Inflammatory Bowel Disease Flares: A 28-Month Quality Improvement Study
Patients hospitalized with inflammatory bowel disease (IBD) flares are at risk of chronic steroid use when they are discharged without a clear prednisone tapering plan (and steroid-sparing treatment strategy) or gastroenterology follow-up. Our quality … Continue reading
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TVB-2640 (FASN inhibitor) for the treatment of nonalcoholic steatohepatitis: FASCINATE-1, a randomized, placebo-controlled Ph2a trial
Increased de novo lipogenesis creates excess intrahepatic fat and lipotoxins, propagating liver damage in nonalcoholic steatohepatitis (NASH). TVB-2640, a fatty acid synthase (FASN) inhibitor, was designed to reduce excess liver fat and directly inhibi… Continue reading
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Unlocking the mind might be critical in management of eosinophilic esophagitis: Expanding beyond drugs, dilation, and diet
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PATHOPHYSIOLOGY AND BIOMARKER POTENTIAL OF FATTY ACID ETHYL ESTER ELEVATION DURING ALCOHOLIC PANCREATITIS
The role of fatty acid ethyl esters (FAEEs) during human alcoholic pancreatitis is unknown. We compared FAEE levels to their non-esterified fatty acids (NEFA) precursors during alcohol intoxication and clinical alcoholic pancreatitis. The pathophysiolo… Continue reading
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AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53
Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells’ neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected … Continue reading
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