Author Archives: Gastroenterology Journal
Familial burden and other clinical factors associated with various types of cancer in individuals with Lynch syndrome
Lynch syndrome (LS) is associated with increased risks of various gastrointestinal, gynecologic, genitourinary, and other cancers. Many clinical practice guidelines recommend that LS carriers’ screening strategies be devised based on their family histo… Continue reading
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Artificial Sweeteners and Whole-food Science: Could Mice Help Clinicians Make Diet Recommendations for IBD Patients?
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Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation
Genetic mutations or regulatory failure underlies cellular malfunction in many diseases including colorectal cancer (CRC) and Inflammatory bowel diseases (IBD). However, mutational defects alone fail to explain the complexity of such disorders. Epigene… Continue reading
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The Evolution of Biologics Administration From Intravenous to Subcutaneous: Treatments for Inflammatory Bowel Disease Goes Home
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Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms
The etiology of cholestasis remains unknown in many children. We surveyed the genome of children with chronic cholestasis for variants in genes not previously associated with liver disease and validated their biological relevance in zebrafish and murin… Continue reading
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Distinct autoantibodies against endothelial protein C receptor in ulcerative colitis
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Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors
Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early-life. Continue reading
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Alcohol Policies and Alcohol-Related Liver Disease Mortality
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Response: AGA Clinical Practice Guideline on the Gastrointestinal Evaluation of Iron Deficiency Anemia
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