Author Archives: Gastroenterology Journal
X chromosome contribution to the genetic architecture of primary biliary cholangitis
Genome-wide association studies (GWAS) in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually-dimorphic complex autoimmun… Continue reading
Commentary on the AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia
Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease
A large unmet therapeutic need exists in inflammatory bowel diseases (IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a complete IL-6/IL-6R blockade is limited by profound immunosuppression. Evidence has e… Continue reading
B lymphocytes contribute to celiac disease pathogenesis
Impact of COVID-19 Pandemic on Gastrointestinal Procedures and Cancers in the United States. A Multicenter Research Network Study.
Impact of COVID-19 Pandemic on Gastrointestinal Procedures and Cancers in the United States. A Multicenter Research Network Study.
Induction and long-term follow-up with ABX464 for moderate-to-severe ulcerative colitis: Results of phase 2a trial
Six versus twelve sessions of gut-focused hypnotherapy for irritable bowel syndrome: a randomized trial
Serotonin Deficiency is Associated with Delayed Gastric Emptying
Gastrointestinal (GI) motility is regulated by serotonin (5-hydroxytryptamine, 5-HT), which is primarily produced by enterochromaffin (EC) cells in the GI tract. However, the precise roles of EC cell-derived 5-HT in regulating gastric motility remain a… Continue reading
Gut microbiota perturbation in IgA deficiency is influenced by IgA-autoantibody status
Immunoglobulin A (IgA) exerts its primary function at mucosal surfaces where it binds microbial antigens to regulate bacterial growth and epithelial attachment. One-third of individuals with IgA deficiency (IgAD) suffer from recurrent mucosal infection… Continue reading