Author Archives: Gastroenterology Journal
Assessing Risk for Gastrointestinal Cancers: Forewarned Is Forearmed…˙
“Prediction is very difficult especially if it’s about the future.” — Niels Bohr Continue reading
Artificial Intelligence enabled histological prediction of remission or activity and clinical outcomes in ulcerative colitis
Microscopic inflammation has significant prognostic value in ulcerative colitis (UC); however, its assessment is complex with high interobserver variability. We aimed to develop and validate an artificial intelligence (AI) Computer-Aided Diagnosis Syst… Continue reading
Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Towards Goblet Cells
Fibrosis and tissue stiffening are hallmarks of the inflammatory bowel disease (IBD). We have hypothesized that the increased stiffness directly contributes to the dysregulation of the epithelial cell homeostasis in IBD. Here, we aim to determine the i… Continue reading
Reimagining Gastroenterology Fellowship Training: The Third Year of the Future
Implementing change in medical education is increasingly being recognized as an opportunity “to best address the workplace needs of our current and future health care system.”1 Capable physicians provide safe, equitable, and patient-centered care. They… Continue reading
A Case of an Incidental Pancreatic Cyst
Disruption of SLFN11 deficiency-induced CCL2 signaling and macrophage M2 polarization potentiates anti-PD-1 therapy efficacy in hepatocellular carcinoma
The therapeutic effect of immune checkpoint inhibitors (ICIs) is poor in hepatocellular carcinoma (HCC) and varies greatly among individuals. Schlafen (SLFN) family members have important functions in immunity and oncology, but their roles in cancer im… Continue reading
SPHINGOLIPIDS ARE DEPLETED IN ALCOHOL-RELATED LIVER FIBROSIS
Alcohol disturbs hepatic lipid synthesis and transport, but the role of lipid dysfunction in alcohol-related liver disease (ALD) is unclear. In this biopsy-controlled, prospective, observational study, we characterized the liver and plasma lipidomes in… Continue reading
Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress
Although small patient subsets benefit from current targeted strategies or immunotherapy, gemcitabine remains the first-line drug for pancreatic cancer (PC) treatment. However, gemcitabine resistance is widespread and compromises long-term survival. He… Continue reading
Promoting Prognostic Understanding and Health Equity for Patients With Advanced Liver Disease: Using “Best Case/Worst Case”
There are emerging data revealing disparities in serious illness care for patients with advanced liver disease. Although liver disease is the 11th leading cause of death overall in adults in the United States, it is the 4th and 7th leading cause of dea… Continue reading
Colorectal Cancer Risk Assessment and Precision Approaches to Screening: Brave New World or Worlds Apart?
Current colorectal cancer (CRC) screening recommendations take a one-size-fits-all approach using age as the major criterion to initiate screening. Precision screening that incorporates factors beyond age to risk stratify individuals could improve upon… Continue reading