Author Archives: Gastroenterology Journal

“Prediction is very difficult especially if it’s about the future.” — Niels Bohr Continue reading →

Microscopic inflammation has significant prognostic value in ulcerative colitis (UC); however, its assessment is complex with high interobserver variability. We aimed to develop and validate an artificial intelligence (AI) Computer-Aided Diagnosis Syst… Continue reading →

Fibrosis and tissue stiffening are hallmarks of the inflammatory bowel disease (IBD). We have hypothesized that the increased stiffness directly contributes to the dysregulation of the epithelial cell homeostasis in IBD. Here, we aim to determine the i… Continue reading →

Implementing change in medical education is increasingly being recognized as an opportunity “to best address the workplace needs of our current and future health care system.”1 Capable physicians provide safe, equitable, and patient-centered care. They… Continue reading →

The therapeutic effect of immune checkpoint inhibitors (ICIs) is poor in hepatocellular carcinoma (HCC) and varies greatly among individuals. Schlafen (SLFN) family members have important functions in immunity and oncology, but their roles in cancer im… Continue reading →

Alcohol disturbs hepatic lipid synthesis and transport, but the role of lipid dysfunction in alcohol-related liver disease (ALD) is unclear. In this biopsy-controlled, prospective, observational study, we characterized the liver and plasma lipidomes in… Continue reading →

Although small patient subsets benefit from current targeted strategies or immunotherapy, gemcitabine remains the first-line drug for pancreatic cancer (PC) treatment. However, gemcitabine resistance is widespread and compromises long-term survival. He… Continue reading →

There are emerging data revealing disparities in serious illness care for patients with advanced liver disease. Although liver disease is the 11th leading cause of death overall in adults in the United States, it is the 4th and 7th leading cause of dea… Continue reading →

Current colorectal cancer (CRC) screening recommendations take a one-size-fits-all approach using age as the major criterion to initiate screening. Precision screening that incorporates factors beyond age to risk stratify individuals could improve upon… Continue reading →