Author Archives: Gastroenterology Journal
Integrated multi-omics Landscape of liver metastases
Lack of thorough knowledge for complicated immune-microenvironment (IM) within a variety of liver metastases (LMs) leads to inappropriate treatment and unsatisfactory prognosis. We aimed to characterize IM subtypes and investigate potential mechanisms … Continue reading
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PTEN deficiency facilitates exosome secretion and metastasis in cholangiocarcinoma by impairing TFEB-mediated lysosome biogenesis
In eukaryotes, the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP) are essential for maintaining cellular proteostasis and associated with cancer progression. Our previous studies have demonstrated that phosphatase and tensin… Continue reading
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A new evaluation method for remission of ulcerative colitis
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Letter to Editor regarding “Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508” by Keiji Nihei et al
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AGA Clinical Practice Guideline on Pharmacological Interventions for Adults With Obesity
Pharmacological management of obesity improves outcomes and decreases the risk of obesity-related complications. This American Gastroenterological Association guideline is intended to support practitioners in decisions about pharmacological interventio… Continue reading
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Identifying Care Challenges as Opportunities for Research and Education in Inflammatory Bowel Disease in South Asia
South Asia (SA) comprises Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka. Despite a growing incidence of inflammatory bowel disease (IBD) in the South Asian population and global South Asian diaspora, the unique needs … Continue reading
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Shining a Light on Barrier Function
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Promote or prevent? Gut microbial function and immune status may determine the effect of fiber in IBD
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Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance.
CRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTOR… Continue reading
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Loss of SUV420H2-dependent chromatin compaction drives right-sided colon cancer progression
Epigenetic processes regulating gene expression contribute markedly to epithelial cell plasticity in colorectal carcinogenesis. The lysine methyltransferase SUV420H2 comprises an important regulator of epithelial plasticity and is primarily responsible… Continue reading
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