Author Archives: Gastroenterology Journal
The Ephrin B2 Receptor Tyrosine Kinase is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett’s Neoplasia
Mechanisms contributing to the onset and progression of Barrett’s (BE)-associated esophageal adenocarcinoma (EAC) remain elusive. Here, we interrogated the major signaling pathways deregulated early in the development of Barrett’s neoplasia. Continue reading
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Independent validation and assay standardization of improved metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis
Pancreatic cancer (PDAC) is a highly lethal malignancy, requiring efficient detection when the primary tumor is still resectable. We had previously developed the MxPancreasScore comprising nine analytes and serum CA19-9, achieving an accuracy of 90.6%…. Continue reading
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AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation
Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medicati… Continue reading
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AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder associated with significant disease burden. This American Gastroenterological Association Guideline is intended to support practitioners in decisions about the use of medic… Continue reading
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An unexpected esophageal lesion in a patient with Muir-Torre Syndrome
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Abdominal Pain Following Transarterial Chemoembolisation
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An unusual presentation of an appendiceal adenocarcinoma
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SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20/CCR6-mediated inflammation
We previously reported that colon epithelial cell silencing of Smad4 increased epithelial expression of inflammatory genes, including the chemokine CCL20, and increased susceptibility to colitis-associated cancer. Here, we examine the role of the chemo… Continue reading
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A rare cause of repeated life-threatening gastrointestinal bleeding
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