Author Archives: Gastroenterology Journal
THE EFFECTS OF HIGH-FAT, LOW-FAT, AND SUCROSE-FREE DIETS ON MICE WITH INNATE IMMUNE MEDIATED COLITIS
While the cause of Inflammatory bowel disease (IBD) is unknown, certain symptoms may be altered by a multitude of factors including genetics, lifestyle choices, and diet choices. High fat diets (HFDs) are diets with fat accounting for ≥20% of total cal… Continue reading
ADEQUACY OF SIGMOIDOSCOPY IN COMPARISION TO COLONOSCOPY TO ASSESS DISEASE ACTIVITY DURING FOLLOW UP IN PATIENTS WITH ULCERATIVE COLITIS
Endoscopic remission is the current treatment target in patients with Ulcerative Colitis (UC). Literature on adequacy of sigmoidoscopy in comparison to colonoscopy to assess endoscopic and histologic activity during follow up is sparse. Continue reading
SIMPLE SUGAR TRIGGERS SPONTANEOUS COLITIS DEVELOPMENT IN IL10-/- MICE
The Western diet characterized by high fat and high sugar is considered a risk factor for inflammatory bowel disease (IBD) such as colitis. However, the precise role of sugar in colitis pathogenesis is poorly understood. We, therefore, investigated the… Continue reading
INTERLEUKIN-17 RECEPTOR SIGNALING TO PANETH CELLS HELPS MAINTAIN INTESTINAL INTEGRITY AFTER GAMMA RADIATION INDUCED INJURY
IL-17A/F signaling through the IL-17RA/RC receptor complex plays a vital role in immunity and inflammation. The expression of IL-17RA/RC by diverse intestinal epithelial cell types including Paneth cells and the observation that therapies neutralizing … Continue reading
ACUITY OF PEDIATRIC INFLAMMATORY BOWEL DISEASE ADMISSIONS PRE AND DURING THE COVID-19 PANDEMIC
The COVID19 pandemic has introduced new challenges to the diagnosis and management of pediatric Inflammatory Bowel Disease (IBD). Many patients have had limited access to their providers through telemedicine and may choose to delay non-emergent treatme… Continue reading
THE USE OF IMMUNOSTAINING IN BIOPSIES TO EVALUATE EXPRESSION PATTERN AND PATHOPHYSIOLOGY ROLES OF ONCOSTATIN M AND ITS RECEPTOR BETA IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
The mRNA expression of oncostatin M (OSM) in colonic tissue is raised in inflammatory bowel disease (IBD) and is mplicated in anti-TNF treatment resistance. OSM has multiple homeostatic functions with both pathogenic and protective roles. Still, its fu… Continue reading
DEVELOPMENT AND VALIDATION OF A MACHINE LEARNING TOOL FOR EARLY DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE IN THE PRIMARY CARE SETTING: A POPULATION BASED STUDY
Although 3,000,000 Americans are afflicted with Inflammatory Bowel Disease (IBD) encompassing Crohn’s Disease (CD) and Ulcerative Colitis (UC)1, timely diagnosis is a challenge due to non-specific and overlapping symptoms.2 More than 20% of patients ma… Continue reading
AMINO ACID SENSING PATHWAYS IN INFLAMMATORY BOWEL DISEASE
IBD is a chronic inflammatory disease of the gastrointestinal tract affecting millions of people worldwide. The last few decades have seen rapid increase of IBD cases in the US contributing to exorbitant health-care costs and morbidity rates. IBD compr… Continue reading
RISK FACTORS FOR DEVELOPMENT OF PROSTATE CANCER IN PATIENT WITH INFLAMMATORY BOWEL DISEASE (IBD)
Prostate cancer (PC) is a 2nd leading cause of cancer death in the USA among men. We aim to investigate incidence, characteristics, and risk factors for PC in patients diagnosed with Inflammatory bowel disease (IBD) using Cerner Health Facts, a nationa… Continue reading
DIET-ASSOCIATED INFLAMMATION, PHYSICAL ACTIVITY, AND HEALTH-RELATED OUTCOMES IN ULCERATIVE COLITIS
Individuals diagnosed with Ulcerative Colitis (UC) often seek complementary lifestyle methods, such as diet and physical activity, to self-manage disease symptoms and respond to the psychosocial challenges of living with chronic illness. The Energy Adj… Continue reading