Author Archives: Jessica Ai-jia Liu, Frank Pui-Ling Lai, Hong-Sheng Gui, Mai-Har Sham, Paul Kwong-Hang Tam, Maria-Mercedes Garcia-Barcelo, Chi-Chung Hui, Elly Sau-Wai Ngan
Identification of GLI Mutations in Patients with Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice
Hirschsprung disease is characterized by a deficit in enteric neurons, which are derived from neural crest cells (NCCs). Aberrant hedgehog signaling disrupts NCC differentiation and might cause Hirschsprung disease. We performed genetic analyses to det… Continue reading
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