Author Archives: Li Wen, Svetlana Voronina, Muhammad A. Javed, Muhammad Awais, Peter Szatmary, Diane Latawiec, Michael Chvanov, David Collier, John Barrett, Malcolm Begg, Ken Stauderman, Jack Roos, Sergey Grigoryev, Stephanie Ramos, Evan Rogers, Jeff Whitten, Gonul V

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

Posted on April 24, 2015 by Li Wen, Svetlana Voronina, Muhammad A. Javed, Muhammad Awais, Peter Szatmary, Diane Latawiec, Michael Chvanov, David Collier, John Barrett, Malcolm Begg, Ken Stauderman, Jack Roos, Sergey Grigoryev, Stephanie Ramos, Evan Rogers, Jeff Whitten, Gonul V

Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium modulator ORAI1 is the most abundant Ca2+ entry channel in pancreatic acinar cells; it sustains … Continue reading →

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