Author Archives: Marieke J.H. Coenen, Dirk J. de Jong, Corine J. van Marrewijk, Luc J.J. Derijks, Sita H. Vermeulen, Dennis R. Wong, Olaf H. Klungel, Andre L.M. Verbeek, Piet M. Hooymans, Wilbert H.M. Peters, Rene H.M. te Morsche, William G. Newman, Hans Scheffer, He
Identification of Patients With Variants in and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease
More than 20% of patients with inflammatory bowel disease (IBD) discontinue thiopurine therapy because of severe adverse drug reactions (ADRs); leukopenia is one of the most serious ADRs. Variants in the gene encoding thiopurine S-methyltransferase (TP… Continue reading
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