Author Archives: Paolo Biancheri, Randall J. Brezski, Antonio Di Sabatino, Allison R. Greenplate, Keri L. Soring, Gino R. Corazza, Klaartje B. Kok, Laura Rovedatti, Anna Vossenkämper, Nadja Ahmad, Susanne A. Snoek, Severine Vermeire, Paul Rutgeerts, Robert E. Jordan,

Proteolytic Cleavage and Loss of Function of Biologic Agents that Neutralize Tumor Necrosis Factor in the Mucosa of Patients with Inflammatory Bowel Disease

Posted on July 10, 2015 by Paolo Biancheri, Randall J. Brezski, Antonio Di Sabatino, Allison R. Greenplate, Keri L. Soring, Gino R. Corazza, Klaartje B. Kok, Laura Rovedatti, Anna Vossenkämper, Nadja Ahmad, Susanne A. Snoek, Severine Vermeire, Paul Rutgeerts, Robert E. Jordan,

Many patients with inflammatory bowel disease (IBD) fail to respond to anti-tumor necrosis factor (TNF) agents such as infliximab and adalimumab, and etanercept is not effective in treatment of Crohn’s disease. Activated matrix metalloproteinase 3 (M… Continue reading →

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