Author Archives: Sonja M. Wörmann, Liang Song, Jiaoyu Ai, Kalliope N. Diakopoulos, Magdalena U. Kurkowski, Kivanc Görgülü, Dietrich Ruess, Andrew Campbell, Claudio Doglioni, Duncan Jodrell, Albrecht Neesse, Ihsan E. Demir, Angelica-Phaedra Karpathaki, Maxim Barenboim

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Posted on March 19, 2016 by Sonja M. Wörmann, Liang Song, Jiaoyu Ai, Kalliope N. Diakopoulos, Magdalena U. Kurkowski, Kivanc Görgülü, Dietrich Ruess, Andrew Campbell, Claudio Doglioni, Duncan Jodrell, Albrecht Neesse, Ihsan E. Demir, Angelica-Phaedra Karpathaki, Maxim Barenboim

One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and … Continue reading →

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