Category Archives: News
Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK blockade and CD40 Agonism
Pancreatic ductal adenocarcinoma (PDA) patients have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly immunosuppressive tumor microenvironment (TME). MEK inhibition combined with autophagy inhibition lead… Continue reading
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COVID-19 mRNA Vaccine Short-Term Safety in Patients with Inflammatory Bowel Disease
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“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development
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“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development
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Single Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution
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Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database
While gastroparesis carries a considerable healthcare and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and dise… Continue reading
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Cyclooxygenases and Prostaglandins in Tumor Immunology and Microenvironment of Gastrointestinal Cancer
Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) suppress the incidence, growth, and metastasis of gastrointestinal cancer supports the concept that an NSAID target… Continue reading
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Transferable IgA-coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation
Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transferable microbiota and… Continue reading
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In Memoriam: Michael N. Marsh, BTh, DPhil, DM, DSc, FRCP
With personal regret, we note the death of Professor Michael N. Marsh. For more than 50 years, the name Marsh has dominated not only the world of celiac disease but additionally the fields of intestinal morphology and immunopathology, promoting the acc… Continue reading
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Epithelial XBP1 coordinates TP53-driven DNA damage responses and suppression of intestinal carcinogenesis
Welz et al. show that XBP1 coordinates epithelial stem cell function in response to DNA damage in a mechanism involving the tumor suppressor TP53. Continue reading
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