Category Archives: News
713b A Multi-Systems Approach with Big Data from Adverse Event Reporting and Health Records, Clinical Biospecimens, and Experimental Animal Data Reveal That Retinoids Impact Asparaginase-Associated Pancreatitis Outcomes in Leukemic Patients
Asparaginase is a crucial cornerstone chemotherapy for the most common cancer in children, acute lymphoblastic leukemia (ALL). However, a major concern is that 5-10% of all asparaginase users develop the painful, life-threatening complication of pancre… Continue reading
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AGA Clinical Practice Update on Strategies to Improve Quality of Screening and Surveillance Colonoscopy: Expert Review
The purpose of this American Gastroenterological Association Institute Clinical Practice Update was to review the available evidence and provide best practice advice regarding strategies to improve the quality of screening and surveillance colonoscopy…. Continue reading
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775a Risankizumab Induction Therapy in Patients With Moderate-to-Severe Crohn’s Disease with Intolerance or Inadequate Response to Conventional and/or Biologic Therapy: Results from the Phase 3 ADVANCE Study
Risankizumab (RZB) is a monoclonal antibody against interleukin-23, a key cytokine in the pathogenesis of inflammatory bowel disease. Phase 2 studies have shown efficacy and safety of RZB in patients with Crohn’s disease (CD). Here we report results of… Continue reading
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713a Mining the Gut Microbiota for Novel Procarcinogenic Microbes Reveals Clostridioides difficile as a Driver of Colonic Tumorigenesis
Microbial studies in colorectal cancer (CRC) have largely focused on three species: colibactin-producing E. coli, enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum. However, not all CRC patients harbor these organisms, suggesting that e… Continue reading
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Information for Authors and Readers
Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage … Continue reading
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713f Histologic Activity in Ulcerative Colitis Patients Achieving Endoscopic Healing is Associated with Higher Rate of Relapse and a Distinct Mucosal Microbial and Transcriptional Profile
Histologic remission (HR) in ulcerative colitis (UC) has been associated with better clinical outcomes. However, this therapeutic target is hard to achieve with the available medications. We aim to assess the relapse-free survival (RFS) of patients wit… Continue reading
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713e Longitudinal Analysis in A HNF4AΔIEC Mouse Colitis Model Reveals that Preclinical Flaring is Associated with Increased Akkermansia muciniphila Levels in the Gut Microbiome
As inflammatory bowel diseases (IBD) develop, the host’s homeostatic relationship with their microbiota changes. Early “preclinical” stages of colitis are relatively understudied, especially with respect to host-microbiota interactions. Intestinal epit… Continue reading
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