Category Archives: News
Abdominal pain as the first manifestation of a systemic disease
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Editorial to accompany Gastro-D-21-00516-R2 Metabolic Surveillance for those at High Risk for Developing Pancreatic Cancer
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Immune Checkpoint Inhibitor Colitis: Resident Memory Unleashed
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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-induced Pancreatic Cancer Progression
SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) remains u… Continue reading
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Total vitamin D intake and risks of early-onset colorectal cancer and precursors
Vitamin D has been implicated in colorectal cancer (CRC) pathogenesis, but it remains unknown whether total vitamin D intake is associated with early-onset CRC and precursors diagnosed before age 50. Continue reading
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Multi-omics analyses show disease, diet, and transcriptome interactions with the virome
The gut virome includes eukaryotic viruses and bacteriophages that can shape the gut bacterial community and elicit host responses. The virome may be implicated in diseases such as irritable bowel syndrome (IBS), where gut bacteria play an important ro… Continue reading
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BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Inflammatory Bowel Disease: Preliminary Real World Data during Mass Vaccination Campaign
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Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model
DNA mismatch repair deficiency (MMRD) drives microsatellite instability (MSI). Cells with MSI accumulate numerous frameshift mutations. Frameshift mutations affecting cancer-related genes may promote tumorigenesis and, therefore, are shared among indep… Continue reading
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Targeting of the Tec kinase ITK drives resolution of T cell-mediated colitis and emerges as potential therapeutic option in ulcerative colitis
The molecular checkpoints driving T cell activation and cytokine responses in ulcerative colitis are incompletely understood. Here, we studied the Tec kinase ITK in ulcerative colitis. Continue reading
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Can FMT cause or prevent CRC? Maybe, but there is more to consider.
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