Category Archives: News
Circular RNA circHIPK3 promotes homeostasis of the intestinal epithelium by reducing miR-29b function
S: Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs that form covalently closed circles. Although circRNAs influence many biological processes, little is known about their role in intestinal epithelium homeostasis. We surveyed circRNAs… Continue reading
A pilot study on automatic 3D quantification of Barrett’s esophagus for risk stratification and therapy monitoring
Barrett’s epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett’s e… Continue reading
Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10-/- mice
Perturbations in the early life gut microbiome are associated with increased risk for complex immune disorders like inflammatory bowel diseases. We previously showed maternal antibiotic-induced gut dysbiosis vertically transmitted to offspring increase… Continue reading
Recurrent Epistaxis and Diffuse Hepatic and Splenic Vascular Malformations
WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the upregulation of IL33 in response to injury
WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of… Continue reading
Tumor-specific delivery of 5FU-incorporated EGFR-targeted aptamers as an efficient treatment in pancreatic ductal adenocarcinoma models
Fluoropyrimidine 5-fluorouracil (5FU) increasingly represents the chemotherapeutic backbone for neoadjuvant, adjuvant and palliative treatment of pancreatic ductal adenocarcinoma (PDAC). Even in combination with other agents, 5FU efficacy remains trans… Continue reading
Bariatric surgery and cancer risk in NAFLD – Effective intervention for a select few
Hybrid stomach-intestinal chromatin states underlie human Barrett’s metaplasia
Tissue metaplasia is uncommon in adults because established cis-element programs resist rewiring. In Barrett’s esophagus, the distal esophageal mucosa acquires predominantly intestinal character, with notable gastric features, and is predisposed to dev… Continue reading