Category Archives: News
Ampullary tumor with a rare etiology: A new lesion in the residual ampulla following curative resection of the perihilar cholangiocarcinoma
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A rare presentation of lower abdominal pain
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TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes.
Pancreatic ductal adenocarcinoma (PDAC) is characterised by advanced disease stage at presentation, aggressive disease biology and resistance to therapy resulting in extremely poor five-year survival Continue reading
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A rare cause of small bowel thickening
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Genetic and epigenetic characteristics of inflammatory bowel disease associated colorectal cancer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct pathway of tumorigenesis compared to sporadic CRC (sCRC). O… Continue reading
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Sugary truth of early-onset colorectal neoplasia – not so sweet after all
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Does Fatherhood Matter? Preconception Use of Biologics and Immunomodulators by Fathers With Immune-Mediated Diseases and Birth Outcomes of Their Offspring
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Artificial Intelligence for the Evaluation of Mucosal Healing in IBD: The Future is Here
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MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment
The metabolic features and function of intratumoral Tregs are ambiguous in colorectal cancer. Tumor-infiltrating Tregs are reprogrammed to exhibit high glucose-depleting properties and adapt to the glucose-restricted microenvironment. The glucose-respo… Continue reading
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Colonic Motility is Improved by the Activation of 5-HT2B Receptors on Interstitial Cells of Cajal in Diabetic Mice
Constipation is commonly associated with diabetes. Serotonin (5-HT), produced predominantly by enterochromaffin (EC) cells via tryptophan hydroxylase 1 (TPH1), is a key modulator of gastrointestinal (GI) motility. However, the role of serotonergic sign… Continue reading
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