Category Archives: News
Model Organisms Help Define the ABCs of Neonatal Cholestasis
Impact of Antibiotic Resistance Genes in Gut Microbiome of Patients with Cirrhosis
Cirrhosis is associated with changes in intestinal microbiota that can lead to hepatic encephalopathy (HE) and infections, especially with antibiotic-resistant organisms. However, the impact of gut microbial antibiotic resistance gene (ARG) burden on c… Continue reading
Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs
The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (mi… Continue reading
A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans
Hypothalamic melanocortin 4 receptors (MC4R) are a key regulator of energy homeostasis. Brain-penetrant MC4R agonists have failed, as concentrations required to suppress food intake also increase blood pressure. However, peripherally located MC4R may a… Continue reading
Covering the Cover
Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients Continue reading
Human microbiota flagellins drive adaptive immune responses in Crohn’s disease
Crohn’s Disease (CD) and ulcerative colitis (UC) are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we devel… Continue reading
Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for Helicobacter pylori Infection: a Network Meta-Analysis.
A number of double, triple and quadruple therapies have been proposed as first line H. pylori infection empiric treatments. However, knowledge of their worldwide and regional comparative efficacy is lacking. We examined the comparative effectiveness of… Continue reading
Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome
Lynch syndrome is associated with pathogenic variants in 4 mismatch repair (MMR) genes that increase lifetime risk of colorectal cancer (CRC). Guidelines recommend intensive CRC surveillance with colonoscopy every 1–2 years starting at 25 years for all… Continue reading