Category Archives: News
DETERMINANTS OF INFLAMMATORY BOWEL DISEASE PATIENT SATISFACTION AFTER TRANSITION TO VIRTUAL VISITS
Due to COVID-19, traditional inflammatory bowel disease (IBD) patient and provider office-based interactions have shifted to telemedicine platforms to address the ongoing healthcare needs of this population. As telehealth services continue to expand, a… Continue reading
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TRANSFER RNA QUEUOSINE MODIFICATION ENZYME MANIPULATES TIGHT JUNCTION PROTEINS IN INFLAMMATORY BOWEL DISEASE
Transfer RNA (tRNA) queuosine (Q)-modification occur at the wobble anticodon position of four special cellular tRNAs. In eukaryotes, tRNA-Q modification relies on the intestinal microbial product queuine and eukaryotic tRNA-guanine transglycosylase com… Continue reading
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EXCESSIVE WEIGHT GAIN IN PEDIATRIC INFLAMMATORY BOWEL DISEASE PATIENTS ON ANTI-TNF THERAPY
Limited studies in patients with inflammatory bowel disease (IBD) suggest that anti-TNF therapy may be associated with excessive weight gain. The objective of this study was to compare the change in BMI z-score in children with Crohn Disease (CD) on an… Continue reading
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IS ILEOANAL POUCH EXCISION A DESTINATION THERAPY FOR INFLAMMATORY BOWEL DISEASE? DATA FROM A QUATERNARY POUCH REFERRAL CENTER
Although ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice of many patients with ulcerative colitis and other conditions, some patients may require pouch excision (PE). We aimed to describe our experience with pouch excisions and … Continue reading
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DISEASE ACTIVITY, STERIOD-FREE REMISSION, AND CLINICAL OUTCOME ASSESSMENTS OF PEDIATRIC ULCERATIVE COLITIS AND CROHN’S DISEASE PATIENTS RECEIVING BIOLOGIC THERAPY
To assess disease activity, steroid-free remission, and clinical outcome assessments among pediatric UC and CD patients who initiated a biologic after being enrolled in the ICN registry. Continue reading
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IDENTIFYING RELEVANT PATHWAYS AND BIOMARKERS IN CROHN’S DISEASE USING CONTEXTUALIZED METABOLIC NETWORK MODEL
Candidate markers for Crohn’s Disease (CD) may be identified via gene expression-based construction of metabolic networks (MN). These can computationally describe gene-protein-reaction associations for entire tissues and also predict the flux of reacti… Continue reading
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VALIDATION OF HPTM-001, A HUMANIZED CANDIDATE THERAPEUTIC ANTIBODY FOR PROMOTING MUCOSAL WOUND HEALING IN IBD
A hallmark of the clinical course of patients with Inflammatory Bowel Disease (IBD) is poorly healing erosions and ulcers in the intestinal mucosa. Despite the adverse clinical consequences of non-healing mucosal wounds in IBD, current front-line thera… Continue reading
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DIETARY INFLAMMATORY POTENTIAL AND FOOD PATTERNS IN RELATION TO GUT MICROBIOME AMONG CHILDREN WITH CROHN’S DISEASE: A COMPARATIVE STUDY WITH HEALTHY CONTROLS
The microbiome has been suggested to play an important role in the pathogenesis and progression of Crohn’s disease (CD) with the components of a Western diet, in turn, potentially altering the gut microbiome. We conducted an observational study compari… Continue reading
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PHOTOVOICE AS A TOOL TO IMPROVE PATIENT – PROVIDER COMMUNICAITON IN INFLAMMATORY BOWEL DISEASE CLNIIC: A PILOT OF FEASIBILITY STUDY
The emotional health of patients with IBD has been difficult to elucidate in routine IBD care, but is critical to medication adoption, adherence and self-management. Patients often are unsure how to communicate their preferences and concerns to their p… Continue reading
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DIFFERENTIALLY EXPRESSED GENE SIGNATURES OF ULCERATIVE COLITIS DETERMINE NOVEL REGULATORS AND PREDICT RESPONSE TO BIOLOGIC THERAPY
Disease heterogenicity among Ulcerative colitis (UC) patients and their variable responses to therapy is not well understood. Previously, using publicly available transcriptomes from colonic tissue of UC patients, we demonstrated the immune cell landsc… Continue reading
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