Category Archives: News
SAFETY OF AMISELIMOD IN HEALTHY SUBJECTS: RESULTS FROM A PHASE 1 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
To evaluate the safety profile of amiselimod, a selective sphingosine 1-phosphate receptor modulator which has been shown to regulate lymphocyte trafficking and is in development for the treatment of inflammatory bowel disease. Continue reading
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IMPACT OF DIET ON INFLAMMATORY BOWEL DISEASE SYMPTOMS: AN ADOLESCENT VIEWPOINT
Dietary modification shows promise as therapy in inflammatory bowel disease (IBD); however, it is unknown whether adolescents are interested in a dietary approach. Continue reading
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GENETIC POLYMOPRHISMS MAY DIFFERENTIATE BETWEEN COMPLICATED PEDIATRIC SMALL BOWEL VERSUS COLONIC CROHN’S DISEASE
About 9% of pediatric Crohn’s disease (CD) patients experience complications within 3 years from diagnosis in spite of anti-Tumor Necrosis Factor-alpha (anti-TNF) biologic treatment. Within 5 years, such complications may require surgical interventions… Continue reading
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SELF-COMPASSION IN ADOLESCENTS AND YOUNG ADULTS WITH INFLAMMATORY BOWEL DISEASE: RELATIONSHIP OF SELF-COMPASSION TO PSYCHOLOGICAL AND PHYSICAL OUTCOMES
Adolescents and young adults (AYA) with Inflammatory Bowel Disease (IBD) are at increased risk for poor psychological and physical well-being. Self-compassion (i.e., understanding and acceptance towards oneself) has been associated with better psycholo… Continue reading
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VISCERAL FAT INDEX INFORMS RISK OF MEDICALLY REFRACTORY IBD AND NEED FOR SURGERY IN PATIENTS STARTING ANTI-TUMOR NECROSIS FACTOR (TNF) THERAPY
Increased visceral adipose tissue (VAT) is associated with systemic inflammation through amplified production of pro-inflammatory cytokines like TNF-α and interleukin-6. Higher visceral fat index (VFI), which is the ratio of VAT to subcutaneous adipose… Continue reading
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OBSTRUCTED LYMPHATIC TRANSPORT AND LEAKAGE DRIVEN BY MESENTERIC TERTIARY LYMPHOID ORGANS IS A FEATURE OF CROHN’S DISEASE MOUSE MODEL
Pioneer reports of Crohn’s disease (CD) suggested that impaired lymphatic flow might drive its pathogenesis but remains unsettled. Nodules of tertiary lymphoid organs (TLO) are found in association with collecting lymphatic vessels (CLVs) of the mesent… Continue reading
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INFLAMMATORY CYTOKINES AND MICROBIAL LIGANDS AND METABOLITES INTERACT TO MODULATE DUOX2 EXPRESSION AND ACTIVITY
The pathogenesis of inflammatory bowel diseases (IBD) is characterized by a dysregulated crosstalk between the host and the microbiome that leads to the development of inflammation and dysbiosis. Dysbiosis in IBD involves an expansion of Proteobacteria… Continue reading
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Healthy mind, healthy body: chronic depression may pre-date the development of IBD by up to 9 years.
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Reply to the editor’s letter: PAF1 regulates the stemness of pancreatic cancer stem cells
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Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathological features
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