Category Archives: News
TET1 and TDG suppress inflammatory response in intestinal tumorigenesis: implications for colorectal tumors with the CpG Island Methylator Phenotype
Aberrant DNA methylation is frequent in colorectal cancer (CRC), but underlying mechanisms and pathological consequences are poorly understood. Continue reading
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PNPLA3 genotype and diabetes identify patients with non-alcoholic fatty liver disease at high risk of incident cirrhosis
Non-alcoholic fatty liver disease (NAFLD) can progress to cirrhosis and hepatic decompensation, but whether genetic variants influence the rate of progression to cirrhosis or are useful in risk stratification among patients with NAFLD is uncertain. Continue reading
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Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer (HDGC) is a dominantly-inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). HDGC is caused by germline mutations in two genes involved in the epit… Continue reading
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Reply: application of administrative data towards epidemiological research
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Surveillance in Barrett’s Esophagus: Challenges, Progress and Possibilities
Endoscopic surveillance of Barrett’s esophagus (BE), aiming to detect prevalent dysplasia and adenocarcinoma, followed by effective endoscopic treatment, is an integral part of the esophageal adenocarcinoma (EAC) prevention paradigm. However, several l… Continue reading
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SOX9 modulates the transformation of gastric stem cells through biased symmetric cell division
Transformation of stem/progenitor cells has been associated with tumorigenesis in multiple tissues, but in the stomach stem cells have been hard to localize. We therefore aimed to use a combination of several markers in order to better target oncogenes… Continue reading
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LTE response: Serotonin in gastrointestinal disorders: delineating peripheral versus central effects
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Global epidemiology and genetics of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC develops in genetically susceptible individuals who are exposed to risk factors especially in the presence of liver cirrhosis. Significant temporal and geographica… Continue reading
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Not only pSM1 but intramucosal carcinoma should also be considered for ESD because pSM1 invasion is brutal to diagnose, even with magnification
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1TIPS AND TRICKS: STARTING YOUR OWN CONTINUING MEDICAL EDUCATION COURSE
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