Category Archives: News
Minimal risk of drug-induced liver injury with molnupiravir and ritonavir-boosted nirmatrelvir
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Inflammatory Bowel Disease is Associated with Prediagnostic Perturbances in Metabolic Pathways
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Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts
Intestinal fibrosis is a significant complication of Crohn’s disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood. Continue reading
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Molecular markers of response to anti-PD1 therapy in advanced hepatocellular carcinoma
Single agent anti-PD1 checkpoint inhibitors convey outstanding clinical benefits in a small fraction (∼20%) of patients with advanced hepatocellular carcinoma (aHCC) but the molecular mechanisms determining response are unknown. To fill this gap, we he… Continue reading
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Histamine-producing bacteria: the missing link in irritable bowel syndrome?
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Endoscopist Adenoma Detection Rates and their Correlation with Post-colonoscopy Colorectal Cancer
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Context-dependent roles of Hes1 in the adult pancreas and pancreatic tumor formation
The Notch signaling pathway is an important pathway in the adult pancreas and in pancreatic ductal adenocarcinoma (PDAC), with HES1 as the core molecule in this pathway. However, the roles of HES1 in the adult pancreas and PDAC formation remain controv… Continue reading
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Clustering of Esophageal Cancer: Differences by Histology
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