Category Archives: News
A lesson in transcriptional plasticity: Classical identity is silenced, but not lost, in pancreatic ductal adenocarcinoma cell lines
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Altered gut microbiome composition and function are associated with gut barrier dysfunction in healthy relatives of patients with Crohn’s disease
The gut microbiome has been suggested to play a role in gut barrier hemostasis, but data are scarce and limited to animal studies. Therefore, we aimed to assess if alterations in gut microbial composition and functional pathways are associated with gut… Continue reading
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An exosome-based transcriptomic signature for noninvasive, early detection of patients with pancreatic ductal adenocarcinoma: A multicenter cohort study
Pancreatic ductal adenocarcinoma (PDAC) incidence is rising worldwide, and majority of patients present with an unresectable disease at initial diagnosis. Measurement of carbohydrate antigen 19-9 (CA19-9) levels lack adequate sensitivity and specificit… Continue reading
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A Liquid Biopsy Signature for the Detection of Patients with Early-Onset Colorectal Cancer
Early-onset colorectal cancer (EOCRC) is a distinct clinical and molecular entity with poor survival outcomes compared to late onset CRC (LOCRC). Although the incidence of EOCRC is rising, current CRC screening strategies have several limitations in di… Continue reading
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Unexpected finding of an inverted appendix on screening colonoscopy.
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An Unusual Cause of Intractable Hiccup and Intermittent Low Fever
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AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review
Nonalcoholic fatty liver disease (NAFLD) is well recognized as a leading etiology for chronic liver disease, affecting >25% of the US and global populations. Up to 1 in 4 individuals with NAFLD have nonalcoholic steatohepatitis, which is associated wit… Continue reading
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Disclosure and Reflection After an Adverse Event: Tips for Training and Practice
A 73-year-old woman with hypertension and hypothyroidism undergoes a surveillance colonoscopy for a history of nonadvanced adenomas. Her last colonoscopy was 5 years ago where 5 small tubular adenomas were removed with cold snare. A third-year gastroen… Continue reading
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Biogeographic variation and functional pathways of the gut microbiota in celiac disease
Genes and gluten are necessary but insufficient to cause celiac disease (CeD). Altered gut microbiota has been implicated as an additional risk factor. Variability in sampling site may confound interpretation and mechanistic insight, as CeD affects pri… Continue reading
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Regulatory and Clinical Expert Perspective of the 2022 FDA Draft Guidance: Celiac Disease: Developing Drugs for Adjunctive Treatment to a Gluten-Free Diet
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