Category Archives: News
Long-term Outcomes after Endoscopic Submucosal Dissection for Large Colorectal Epithelial Neoplasms: A Prospective, Multicenter, Cohort Trial from Japan
To determine the long-term outcomes after colorectal endoscopic submucosal dissection (ESD), we conducted a large, multicenter, prospective cohort trial with a 5-year observation period. Continue reading
Novel, Emerging Risk Factors for Colorectal Cancer Remain Understudied
For more than 3 decades, colorectal cancer (CRC) incidence rates have been increasing rapidly among adults Continue reading
Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 Mutations
Two patients with homozygous mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea and poor weight gain, the causes of which were not identified through routine clinical testing. We aim to perform a deep analysis of the stomach and int… Continue reading
Treatment of IBS Using FMT: A Step Forward?
Failure to Achieve Target Drug Concentrations During Induction and Not HLA-DQA1*05 Carriage is Associated with Anti-Drug Antibody Formation in Patients with Inflammatory Bowel Disease: HLA-DQA1*05 Testing for Immunogenicity to anti-TNF Remains Relevant in IBD, But Depends on Therapeutic Drug Monitoring Strategy
Diagnostic performance of a non-invasive breath test for colorectal cancer: COBRA1 study
Navigating the Stormy Sea of Infected Necrotizing Pancreatitis: Are We There Yet? Well Almost!
Acute pancreatitis (AP) is associated with significant morbidity and mortality.1 The short-term outcomes in AP are determined both by systemic and local complications. Persistent organ failure, which defines the severity of AP, leads to a high mortalit… Continue reading
Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites
Studies have reported abnormal gut microbiota or circulating metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture the CRC-relevant features consistent across geographic regions. This is particularly the problem for … Continue reading
Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants
Magnetic resonance elastography (MRE) is an accurate biomarker of liver fibrosis, however, limited data characterize its association with clinical outcomes. We conducted individual participant data pooled meta-analysis (IPDMA) on patients with nonalcoh… Continue reading
CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease
Endpoints to determine the efficacy and safety of medical therapies for Crohn’s disease (CD) and ulcerative colitis (UC) are evolving. Given the heterogeneity in current outcome measures, harmonizing endpoints in a core outcome set (COS) for randomized… Continue reading